Interstitial HDR brachytherapy in the treatment of non-melanocytic skin cancers around the eye

CC BY Logo DOI

Background: Eyelid tumors are rare skin cancers, the most common of which is basal cell carcinoma characterized primarily by local growth. In addition to surgery, radiotherapy is among the basic methods of treatment. External beam radiotherapy is associated with the risk of complications within ocular structures, especially the lens. In the case of interstitial brachytherapy, it is possible to administer a high dose to the clinical target volume (CTV), while reducing it in the most sensitive structures.

Methods: This paper presents the results of an analysis of 28 patients treated with interstitial high dose rate (HDR) brachytherapy for skin cancers of the upper and lower eyelid; medial and lateral canthus; and the cheek, nose and temples with the infiltration of ocular structures. The patients were treated according to two irradiation schedules: 49 Gy in 14 fractions of 3.5 Gy twice a day for 7 days of treatment, and 45 Gy in 5 Gy fractions twice a day for 5 days. The mean follow-up was 22 months (3–49 months).

Results: two patients (6%) had a relapse: a local recurrence within the irradiated area in one of them, and metastases to lymph nodes in the other. The most common early complication was conjunctivitis (74%), and the most common late complication was dry eye syndrome (59%).

Conclusions: Interstitial HDR brachytherapy for skin cancers of the upper and lower eyelid; medial and lateral cants; and the cheek, nose and temples with infiltration of ocular structures is a highly effective, short and relatively low burden type of treatment.

Tytuł
Interstitial HDR brachytherapy in the treatment of non-melanocytic skin cancers around the eye
Twórca
Cisek Paweł
Słowa kluczowe
HDR brachytherapy; non-melanocytic skin cancer; cancer around the eye; radiation therapy
Współtwórca
Kieszko Dariusz
Bilski Mateusz
Dębicki Radomir
Grywalska Ewelina
Hrynkiewicz Rafał ORCID 0000-0002-0688-6928
Bębnowska Dominika ORCID 0000-0003-3689-2381
Kordzińska-Cisek Izabela
Rolińska Agnieszka
Niedźwiedzka-Rystwej Paulina ORCID 0000-0003-4065-3842
Grzybowska-Szatkowska Ludmiła
Data
2021
Typ zasobu
artykuł
Identyfikator zasobu
DOI 10.3390/cancers13061425
Źródło
Cancers, 2021, vol. 13 iss. 6, [br. s.], 1425
Język
angielski
Prawa autorskie
CC BY CC BY
Kategorie
Publikacje pracowników US
Data udostępnienia1 paź 2021, 15:04:33
Data mod.18 mar 2022, 08:05:30
DostępPubliczny
Aktywnych wyświetleń0