Impaired innate immunity in pediatric patients type 1 diabetes : focus on toll-like receptors expression

CC BY Logo DOI

Type 1 diabetes (DM1) is classified as an autoimmune disease. An uncontrolled response of B and T lymphocytes to the body’s own tissues develops in the absence of immune tolerance. The main aim of the study was to evaluate the effect of the duration of type 1 diabetes in children on the expression of TLR receptors and the relationship with the parameters of glycemic control in patients. As a result, we showed significant differences in the level of TLR2, TLR4 and TLR9 expression in patients with DM1 in the early stage of the disease and treated chronically compared to the healthy group. Additionally, in this study, we found that the numbers of CD19+ B cells, CD3+ CD4+, CD3+ CD8+ T cells and NK cells are different for newly diagnosed DM1 individuals, patients receiving chronic treatment and for healthy controls, indicating an important role of these cells in killing pancreatic beta cells. Moreover, higher levels of IL-10 in patients with newly diagnosed DM1 have also been found, confirming the reports found in the literature.

Tytuł
Impaired innate immunity in pediatric patients type 1 diabetes : focus on toll-like receptors expression
Twórca
Kurianowicz Katarzyna
Słowa kluczowe
type 1 diabetes mellitus; children; Toll-like receptors; cukrzyca typu 1; dzieci; receptory Toll-podobne
Współtwórca
Klatka Maria
Polak Agnieszka
Hymos Anna
Bębnowska Dominika ORCID 0000-0003-3689-2381
Podgajna Martyna
Hrynkiewicz Rafał ORCID 0000-0002-0688-6928
Sierawska Olga ORCID 0000-0003-3567-7786
Niedźwiedzka-Rystwej Paulina Marta ORCID 0000-0003-4065-3842
Data
2021
Typ zasobu
artykuł
Identyfikator zasobu
DOI 10.3390/ijms222212135
Źródło
International Journal of Molecular Sciences, 2021, vol. 22 iss. 22, [br. s.], 12135
Język
angielski
Prawa autorskie
CC BY CC BY
Kategorie
Publikacje pracowników US
Data udostępnienia18 mar 2022, 12:29:04
Data mod.18 mar 2022, 12:29:04
DostępPubliczny
Aktywnych wyświetleń0