ADIPOQ polymorphisms are associated with changes in obesityrelated traits in response to aerobic training programme in women

CC BY-SA Logo DOI

Among genetic variants of the ADIPOQ gene +276 G>T (rs1501299) and –11377 G>C (rs266729) are the most frequently investigated polymorphisms which were described in the context of genetic conditioning for a predisposition to obesity. However, the information of polymorphisms’ potential modifying effect on obesityrelated traits achieved through training procedures are still unknown. DNA was extracted from buccal cells donated by the 201 participants and genotyping was carried out using real-time PCR. The genotype distribution was examined in a group of women measured for chosen traits before and after the completion of a 12-week training programme. Our results suggest that the ADIPOQ genotypes analyzed individually or in combination can modulate training-induced body mass measurements changes: after the training programme, carriers of rs1501299 T allele and rs266729 C allele were characterized by a greater reduction in fat mass percentage (FM), fat mass, and body mass. Moreover, the ADIPOQ polymorphisms were associated with changes in lipid profile in response to training. Additionally, we showed three main effects of genotypes for the FM, LDL-C (rs266729), and TBW (rs1501299). Our study indicate that the both polymorphisms are associated with changes in obesity-related traits in response to 12-week aerobic training programme in Caucasian women. From this evidence, it could be concluded that rs1501299 G and rs266728 G variants may be considered as disadvantageous factor in the context of training-induced effects on body mass traits.

Tytuł
ADIPOQ polymorphisms are associated with changes in obesityrelated traits in response to aerobic training programme in women
Twórca
Leońska-Duniec Agata ORCID 0000-0001-6787-3760
Słowa kluczowe
ADIPOQ gene; gene x physical activity interaction; training programme; obesity-related traits; gen ADIPOQ; gen x inerakcja aktywności fizycznej; program treningowy; otyłość- powiązane cechy
Współtwórca
Grzywacz Anna
Jastrzębski Zbigniew
Jażdżewska Aleksandra
Lulińska-Kuklik Ewelina
Moska Waldemar
Leźnicka Katarzyna ORCID 0000-0002-9315-5794
Ficek Krzysztof
Rzeszutko Agata
Dornowski Marcin
Cięszczyk Paweł ORCID 0000-0002-7735-7580
Data
2018
Typ zasobu
artykuł
Identyfikator zasobu
DOI 10.5114/biolsport.2018.72762
Źródło
Biology of Sport, 2018, vol. 35 no. 2, pp. 165-173
Język
angielski
Prawa autorskie
CC BY-SA CC BY-SA
Kategorie
Publikacje pracowników US
Data udostępnienia22 mar 2022, 13:39:59
Data mod.22 mar 2022, 13:39:59
DostępPubliczny
Aktywnych wyświetleń0