Immune signature of COVID-19 : in-depth reasons and consequences of the cytokine storm

CC BY Logo DOI

In the beginning of the third year of the fight against COVID-19, the virus remains at least still one step ahead in the pandemic “war”. The key reasons are evolving lineages and mutations, resulting in an increase of transmissibility and ability to evade immune system. However, from the immunologic point of view, the cytokine storm (CS) remains a poorly understood and difficult to combat culprit of the extended number of in-hospital admissions and deaths. It is not fully clear whether the cytokine release is a harmful result of suppression of the immune system or a positive reaction necessary to clear the virus. To develop methods of appropriate treatment and therefore decrease the mortality of the so-called COVID-19-CS, we need to look deeply inside its pathogenesis, which is the purpose of this review.

Tytuł
Immune signature of COVID-19 : in-depth reasons and consequences of the cytokine storm
Twórca
Niedźwiedzka-Rystwej Paulina ORCID 0000-0003-4065-3842
Słowa kluczowe
COVID-19; SARS-CoV-2; viral diseases; cytokines; cytokine storm; immune response; viral response; infection; choroby wirusowe; cytokiny; burza cytokinowa; odpowiedź immunologiczna; odpowiedź wirusowa; infekcja
Współtwórca
Majchrzak Adam
Kurkowska Sara
Małkowska Paulina ORCID 0000-0003-2430-5020
Sierawska Olga ORCID 0000-0003-3567-7786
Hrynkiewicz Rafał ORCID 0000-0002-0688-6928
Parczewski Miłosz
Data
2022
Typ zasobu
artykuł
Identyfikator zasobu
DOI 10.3390/ijms23094545
Źródło
International Journal of Molecular Sciences, 2022, Vol. 23 iss. 9, [br. s.], 4545
Język
angielski
Prawa autorskie
CC BY CC BY
Kategorie
Publikacje pracowników US
Data udostępnienia23 maj 2022, 15:01:57
Data mod.23 maj 2022, 15:01:57
DostępPubliczny
Aktywnych wyświetleń0