Pathophysiology and clinical manifestations of COVID-19-related acute kidney injury : the current state of knowledge and future perspectives

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The continually evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in a vast number of either acute or chronic medical impairments of a pathophysiology that is not yet fully understood. SARS-CoV-2 tropism for the organs is associated with bilateral organ cross-talks as well as targeted dysfunctions, among which acute kidney injury (AKI) seems to be highly prevalent in infected patients. The need for efficient management of COVID-related AKI patients is an aspect that is still being investigated by nephrologists; however, another reason for concern is a disturbingly high proportion of various types of kidney dysfunctions in patients who have recovered from COVID-19. Even though the clinical picture of AKI and COVID-related AKI seems to be quite similar, it must be considered that regarding the latter, little is known about both the optimal management and long-term consequences. These discrepancies raise an urgent need for further research aimed at evaluating the molecular mechanisms associated with SARS-CoV-2-induced kidney damage as well as standardized management of COVID-related AKI patients. The following review presents a comprehensive and most-recent insight into the pathophysiology, clinical manifestations, recommended patient management, treatment strategies, and post-mortem findings in patients with COVID-related AKI.

Tytuł
Pathophysiology and clinical manifestations of COVID-19-related acute kidney injury : the current state of knowledge and future perspectives
Twórca
Smarz-Widelska Iwona
Słowa kluczowe
COVID-19; SARS-CoV-2; acute kidney injury; AKI; survival rate; glomerulopathy; SARS-CoV-2 tropism; coronavirus; ostra niewydolność nerek; wskaźnik przeżycia; granulopatia; tropizm SARS-CoV-2; coronawirus
Współtwórca
Grywalska Ewelina
Morawska Iwona
Forma Alicja
Michalski Adam
Mertowski Sebastian
Hrynkiewicz Rafał ORCID 0000-0002-0688-6928
Niedźwiedzka-Rystwej Paulina Marta ORCID 0000-0003-4065-3842
Korona-Głownia Izabela
Parczewski Miłosz
Załuska Wojciech
Data
2021
Typ zasobu
artykuł
Identyfikator zasobu
DOI 10.3390/ijms22137082
Źródło
International Journal of Molecular Sciences, 2021, vol. 22 iss. 13, [br. s.], 7082
Język
angielski
Prawa autorskie
CC BY CC BY
Kategorie
Publikacje pracowników US
Data udostępnienia30 sie 2021, 10:18:33
Data mod.28 mar 2022, 08:41:28
DostępPubliczny
Aktywnych wyświetleń0