Paving the way toward successful multiple myeloma treatment : chimeric antigen receptor T-cell therapy

CC BY Logo DOI

Despite the significant progress of modern anticancer therapies, multiple myeloma (MM) is still incurable for the majority of patients. Following almost three decades of development, chimeric antigen receptor (CAR) T-cell therapy now has the opportunity to revolutionize the treatment landscape and meet the unmet clinical need. However, there are still several major hurdles to overcome. Here we discuss the recent advances of CAR T-cell therapy for MM with an emphasis on future directions and possible risks. Currently, CAR T-cell therapy for MM is at the first stage of clinical studies, and most studies have focused on CAR T cells targeting B cell maturation antigen (BCMA), but other antigens such as cluster of differentiation 138 (CD138, syndecan-1) are also being evaluated. Although this therapy is associated with side effects, such as cytokine release syndrome and neurotoxicity, and relapses have been observed, the benefit–risk balance and huge potential drive the ongoing clinical progress. To fulfill the promise of recent clinical trial success and maximize the potential of CAR T, future efforts should focus on the reduction of side effects, novel targeted antigens, combinatorial uses of different types of CAR T, and development of CAR T cells targeting more than one antigen. 

Tytuł
Paving the way toward successful multiple myeloma treatment : chimeric antigen receptor T-cell therapy
Twórca
Grywalska Ewelina
Słowa kluczowe
multiple myeloma; chimeric antigen receptor T (CAR T); BCMA; immunotherapy; szpiczak mnogi; chimeryczny receptor antygenowy T; immunoterapia
Współtwórca
Sosnowska-Pasiarska Barbara
Smok-Kalwat Jolanta
Pasiarski Marcin
Niedźwiedzka-Rystwej Paulina ORCID 0000-0003-4065-3842
Roliński Jacek
Data
2020
Typ zasobu
artykuł
Identyfikator zasobu
DOI 10.3390/cells9040983
Źródło
Cells, 2020, vol. 9 iss. 4, [br. s.], 983
Język
angielski
Prawa autorskie
CC BY CC BY
Kategorie
Publikacje pracowników US
Data udostępnienia30 sie 2021, 11:44:44
Data mod.30 sie 2021, 11:44:44
DostępPubliczny
Aktywnych wyświetleń0