Self-reported quality of life in multiple sclerosis patients : preliminary results based on the Polish MS Registry

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Background: The aim of the study was to analyze selected clinical and sociodemographic factors and their effects on the quality of life (QoL) of multiple sclerosis (MS) patients registered in the Polish MS Registry.

Methods: This was a cross-sectional observational study performed in Poland. Data on personal and disease-specific factors were collected between January 1, 2011, and December 31, 2015, via the web portal of the Polish MS Registry. All patients were assessed by a physician and asked to complete the Polish language versions of the following self-evaluation questionnaires: EuroQol 5-Dimensions, EuroQoL Visual Analog Scale, and Multiple Sclerosis Impact Scale. Univariate analysis and logistic regression were performed to determine the factors associated with QoL.

Results: The study included 2,385 patients (female/male ratio 2.3:1) with clinically confirmed MS (mean age 37.8±9.2 years). Average EuroQol 5-Dimensions index was 0.72±0.24, and the mean EuroQoL Visual Analog Scale score was 64.2±22.8. The average Multiple Sclerosis Impact Scale score was 84.6±11.2 (62.2±18.4 for physical condition and 23.8±7.2 for mental condition). Lower QoL scores were significantly associated with higher level of disability (odds ratio [OR], 0.932; 95% confidence interval [CI], 0.876–0.984; P=0.001), age >40 years (OR, 1.042; 95% CI, 0.924–1.158; P=0.012), longer disease duration (OR, 0.482; 95% CI, 0.224–0.998; P=0.042), and lack of disease modifying therapies (OR, 0.024; 95% CI, 0.160–0.835; P=0.024). No significant associations were found between QoL, sex, type of MS course, patient’s education, and marital status.

Conclusion: The Polish MS Registry is the first national registry for long-term observation that allows for self-evaluation of the QoL. QoL of Polish patients with MS is significantly lower compared with the rest of the population. The parameter is mainly affected by the level of disability, duration of the disease, and limited access to immunomodulatory therapy.

Tytuł
Self-reported quality of life in multiple sclerosis patients : preliminary results based on the Polish MS Registry
Twórca
Brola Waldemar
Słowa kluczowe
multiple sclerosis; patient-reported outcomes; quality of life; Poland
Słowa kluczowe
stwardnienie rozsiane; wyniki zgłaszane przez pacjentów; jakość życia; Polska
Współtwórca
Sobolewski Piotr
Fudala Małgorzata
Flaga Stanisław
Jantarski Konrad
Ryglewicz Danuta
Potemkowski Andrzej ORCID 0000-0001-8162-8649
Data
2016
Typ zasobu
artykuł
Identyfikator zasobu
DOI 10.2147/PPA.S109520
Źródło
Patient Preference and Adherence, 2016, vol. 10, pp. 1647-1656
Język
angielski
Prawa autorskie
CC BY-NC CC BY-NC
Kategorie
Publikacje pracowników US
Data udostępnienia11 maj 2023, 10:10:51
Data mod.11 maj 2023, 10:10:51
DostępPubliczny
Aktywnych wyświetleń0