Positive effects of physical activity on insulin signaling

CC BY Logo DOI

Physical activity is integral to metabolic health, particularly in addressing insulin resistance and related disorders such as type 2 diabetes mellitus (T2DM). Studies consistently demonstrate a strong association between physical activity levels and insulin sensitivity. Regular exercise interventions were shown to significantly improve glycemic control, highlighting exercise as a recommended therapeutic strategy for reducing insulin resistance. Physical inactivity is closely linked to islet cell insufficiency, exacerbating insulin resistance through various pathways including ER stress, mitochondrial dysfunction, oxidative stress, and inflammation. Conversely, physical training and exercise preserve and restore islet function, enhancing peripheral insulin sensitivity. Exercise interventions stimulate β-cell proliferation through increased circulating levels of growth factors, further emphasizing its role in maintaining pancreatic health and glucose metabolism. Furthermore, sedentary lifestyles contribute to elevated oxidative stress levels and ceramide production, impairing insulin signaling and glucose metabolism. Regular exercise induces anti-inflammatory responses, enhances antioxidant defenses, and promotes mitochondrial function, thereby improving insulin sensitivity and metabolic efficiency. Encouraging individuals to adopt active lifestyles and engage in regular exercise is crucial for preventing and managing insulin resistance and related metabolic disorders, ultimately promoting overall health and well-being.

Tytuł
Positive effects of physical activity on insulin signaling
Twórca
Małkowska Paulina ORCID 0000-0003-2430-5020
Słowa kluczowe
physical activity; insulin sensitivity; metabolic health; inflammation; insulin signaling; exercise interventions; type 2 diabetes; metabolic syndrome
Słowa kluczowe
aktywność fizyczna; wrażliwość na insulinę; zdrowie metaboliczne; stan zapalny; sygnalizacja insulinowa; interwencje wysiłkowe; cukrzyca typu 2; zespół metaboliczny
Data
2024
Typ zasobu
artykuł
Identyfikator zasobu
DOI 10.3390/cimb46060327
Źródło
Current Issue In Molecular Biology, 2024, vol. 46 iss 6, pp. 5467-5487
Język
angielski
Prawa autorskie
CC BY CC BY
Dyscyplina naukowa
Nauki o kulturze fizycznej; Dziedzina nauk medycznych i nauk o zdrowiu
Kategorie
Publikacje pracowników US
Data udostępnienia5 cze 2024, 14:02:45
Data mod.5 cze 2024, 14:02:45
DostępPubliczny
Aktywnych wyświetleń0