Programmed cell death protein-1 regulation in response to SARS-CoV-2 in paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 : a prospective cohort study

CC BY Logo DOI

The role of programmed death cell protein 1 (PD-1) has already been described in a range of various diseases, including COVID-19. This study provides new, innovative data, related to the expression of PD-1 and the risk of Paediatric Inflammatory Multisystem Syndrome, temporally associated with SARS-CoV-2 infection (PIMS-TS)—a rare, but potentially life-threatening complication of COVID-19. In this study, we evaluated the expression of PD-1 protein in patients with PIMS. Blood samples were taken from patients at the time of diagnosis (n = 33), after 6 weeks (n = 33), 3 months (n = 24), 6 months (n = 24) and 12 months (n = 8). The immunophenotypes were evaluated in flow cytometry. The control group consisted of 35 healthy children with negative SARS-CoV-2 antigen/PCR test, who were asymptomatic and had no history of allergic, autoimmune or oncological diseases. The associations between immunophenotypes, biochemical findings and clinical data were analysed. Significant increases in the expression of PD-1 for CD4+ and CD8+ T cells, compared to the control group, were observed in the day of admission, with a gradual decrease during the first weeks from initiation of treatment. This study sheds new light on the pathogenesis of PIMS-TS, emphasizing the role of PD-1 protein. Future research is essential for early risk prediction in SARS-CoV-2 patients and for devising effective clinical prevention and management strategies.

Tytuł
Programmed cell death protein-1 regulation in response to SARS-CoV-2 in paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 : a prospective cohort study
Twórca
Opoka-Winiarska Violetta
Słowa kluczowe
programmed cell death protein 1; Paediatric Multisystem Inflammatory Syndrome; severe acute respiratory syndrome coronavirus 2; immunophenotype; lymphocyte
Słowa kluczowe
białko zaprogramowanej śmierci komórki 1; Pediatryczny wieloukładowy zespół zapalny; ostry zespół oddechowy koronawirus 2; immunofenotyp; limfocyt
Współtwórca
Grywalska Ewelina
Morawska-Michalska Izabela
Korona-Głowniak Izabela
Kądziołka Olga
Gosik Krzysztof
Majchrzak Adam
Rahnama-Hezavah Mansur
Niedźwiedzka-Rystwej Paulina Marta ORCID 0000-0003-4065-3842
Data
2024
Typ zasobu
artykuł
Identyfikator zasobu
DOI 10.3390/ijms25115968
Źródło
International Journal of Molecular Sciences, 2024, vol. 25 iss. 11, [br. s.], 5968
Język
angielski
Prawa autorskie
CC BY CC BY
Dyscyplina naukowa
Nauki biologiczne; Dziedzina nauk ścisłych i przyrodniczych
Kategorie
Publikacje pracowników US
Data udostępnienia5 cze 2024, 14:32:22
Data mod.5 cze 2024, 14:32:22
DostępPubliczny
Aktywnych wyświetleń0