Toll-like receptor as a potential biomarker in renal diseases

One of the major challenges faced by modern nephrology is the identification of biomarkers associated with histopathological patterns or defined pathogenic mechanisms that may assist in the non-invasive diagnosis of kidney disease, particularly glomerulopathy. The identification of such molecules may allow prognostic subgroups to be established based on the type of disease, thereby predicting response to treatment or disease relapse. Advances in understanding the pathogenesis of diseases, such as membranous nephropathy, minimal change disease, focal segmental glomerulosclerosis, IgA (immunoglobulin A) nephropathy, and diabetic nephropathy, along with the progressive development and standardization of plasma and urine proteomics techniques, have facilitated the identification of an increasing number of molecules that may be useful for these purposes. The growing number of studies on the role of TLR (toll-like receptor) receptors in the pathogenesis of kidney disease forces contemporary researchers to reflect on these molecules, which may soon join the group of renal biomarkers and become a helpful tool in the diagnosis of glomerulopathy. In this article, we conducted a thorough review of the literature on the role of TLRs in the pathogenesis of glomerulopathy. The role of TLR receptors as potential marker molecules for the development of neoplastic diseases is emphasized more and more often, as prognostic factors in diseases on several epidemiological backgrounds.

Tytuł
Toll-like receptor as a potential biomarker in renal diseases
Twórca
Mertowski Sebastian
Słowa kluczowe
acute kidney injury; biomarker; diabetic nephropathy; focal segmental glomerulosclerosis; innate immunity; membranous nephropathy; minimal change diseases; TLR; ostre uszkodzenie nerek; nefropatia cukrzycowa; ogniskowe segmentalne stwardnienie kłębuszków nerkowych; odporność wrodzona; nefropatia błoniasta; choroby z minimalnymi zmianami
Współtwórca
Lipa Paulina; Morawska Izabela; Niedźwiedzka-Rystwej Paulina ORCID: 0000-0003-4065-3842; Bębnowska Dominika ORCID: 0000-0003-3689-2381; Hrynkiewicz Rafał ORCID: 0000-0002-0688-6928; Grywalska Ewelina; Roliński Jacek; Załuska Wojciech
Data
2020
Typ zasobu
artykuł
Identyfikator zasobu
DOI: 10.3390/ijms21186712
Źródło
International Journal of Molecular Sciences, 2020, vol. 21 iss. 18, [br. s.], 6712
Język
angielski
Prawa autorskie
CC BY
Kategorie
Publikacje pracowników US
Data udostępnienia14 wrz 2021, 14:48:51
Data mod.14 wrz 2021, 14:48:51
DostępPubliczny
Aktywnych wyświetleń0