Innate immune system response to burn damage—focus on cytokine alteration


In the literature, burns are understood as traumatic events accompanied by increased morbidity and mortality among affected patients. Their characteristic feature is the formation of swelling and redness at the site of the burn, which indicates the development of inflammation. This reaction is not only important in the healing process of wounds but is also responsible for stimulating the patient’s innate immune system. As a result of the loss of the protective ability of the epidermis, microbes which include bacteria, fungi, and viruses have easier access to the system, which can result in infections. However, the patient is still able to overcome the infections that occur through a cascade of cytokines and growth factors stimulated by inflammation. Long-term inflammation also has negative consequences for the body, which may result in multi-organ failure or lead to fibrosis and scarring of the skin. The innate immune response to burns is not only immediate, but also severe and prolonged, and some people with burn shock may also experience immunosuppression accompanied by an increased susceptibility to fatal infections. This immunosuppression includes apoptosis-induced lymphopenia, decreased interleukin 2 (IL-2) secretion, neutrophil storm, impaired phagocytosis, and decreased monocyte human leukocyte antigen-DR. This is why it is important to understand how the immune system works in people with burns and during infections of wounds by microorganisms. The aim of this study was to characterize the molecular pathways of cell signaling of the immune system of people affected by burns, taking into account the role of microbial infections.

Innate immune system response to burn damage—focus on cytokine alteration
Sierawska Olga ORCID 0000-0003-3567-7786
Słowa kluczowe
immune system; burns; microorganism; układ odpornościowy; oparzenia; mikroroganizmy
Małkowska Paulina ORCID 0000-0003-2430-5020
Taskin Cansel
Hrynkiewicz Rafał ORCID 0000-0002-0688-6928
Mertowska Paulina
Grywalska Ewelina
Korzeniowski Tomasz
Torres Kamil
Surowiecka Agnieszka
Niedźwiedzka-Rystwej Paulina ORCID 0000-0003-4065-3842
Strużyna Jerzy
Typ zasobu
Identyfikator zasobu
DOI 10.3390/ijms23020716
International Journal of Molecular Sciences, 2022, vol. 23 iss. 2, [br. s.], 716
Prawa autorskie
Publikacje pracowników US
Data udostępnienia10 mar 2022, 14:55:21
Data mod.17 mar 2022, 09:49:48
Aktywnych wyświetleń0