B and T lymphocytes in rabbits change according to the sex and throughout the year


The European rabbit (Oryctolagus cuniculus) is a good model in biomedicine used in research on several human diseases. The reference values of B and T cells and their subpopu- lations are very important to understand how the adaptive immune system is responding to infectious agents. The aim of this study was to determine values of B and T cells and their subpopulations in Polish mixed-breed rabbits, considering seasons of the year and sex. The study was performed on 200 Polish mixed-breed rabbits and the percentage of B and T lymphocytes was measured cytometrically using mouse anti-rabbit antibodies. The study revealed that the season of the year and sex of the animals affected the percentage of B- and T-cells and their subpopulations in peripheral blood. Statistically significant values of CD19+ B-cells in spring and autumn, of T CD5+ cells in spring and winter, of T CD4+ in spring, summer, autumn and winter, of T CD8+ in winter and of T CD25+ in spring were noted. Generally the highest values were found mainly in warm part of the year, while the lowest in colder months. A statistical significance was also observed between males and females – changes were found in T CD4+ and T CD25+ lymphocytes in spring, T CD8+ cells in winter and higher percentage was generally obtained in females than in males. The only exception was the T CD5+ subpopulation in which no differences were observed between the sexes and throughout the year. This is the first paper on adaptive immune system cell values in the European rabbit of domestic breeds.

B and T lymphocytes in rabbits change according to the sex and throughout the year
Niedźwiedzka-Rystwej Paulina ORCID 0000-0003-4065-3842
Słowa kluczowe
rabbit; B and T lymphocytes; reference values
Tokarz-Deptuła Beata ORCID 0000-0001-8308-7284
Abrantes Joana
Esteves J. Pedro
Deptuła Wiesław ORCID 0000-0001-5367-7670
Typ zasobu
Identyfikator zasobu
DOI 10.24425/pjvs.2020.132746
Polish Journal of Veterinary Sciences, 2020, vol. 23 no. 1, pp. 37-42
Prawa autorskie
Publikacje pracowników US
Data udostępnienia30 sie 2021, 14:37:49
Data mod.30 sie 2021, 14:37:49
Aktywnych wyświetleń0